Inositol is a B vitamin, and Inositol Hexaphosphate (IP6) is a phosphorylated version with six phosphates attached. IP6 is also called Phytic Acid or Phytate.
IP6 is a naturally occurring substance found in grains, especially corn, and in legumes. It has several special qualities but perhaps the most dramatic effect of this remarkable substance is that of an anti-cancer agent.
Inositol is the substance that regulates cell division. It has a modulation effect which means that although it has no effect on normal cells, it stops the reproduction of cells which are multiplying too fast, such as cancer cells. It also forces the cells to mature and differentiate. Most cancer cells are immature, unspecialized cells that multiply indefinitely. Inositol stops this. Actually, it is a phosphorylated Inositol that does the trick. Inositol Phosphate comes in six varieties from IP1 to IP6. IP3 is perhaps the most active in regulating cell division, but the exact function of each IP is not known. Inositol is synergistic with IP6 because as phosphates are stripped from the hexaphosphate they are taken up by Inositol, recycling the process.
IP6 is the substance in fiber that prevents colon cancer. Also, studies in Finland show that eating a high fat diet along with a diet rich in this substance yields a much lower incidence of cancer (such as breast cancer), than countries such as the USA with less fat consumption. Inositol Hexaphosphate is among the most powerful cancer prevention substances known, even more so than Green Tea.
Inositol and the phosphate form also combine to defeat cancer that has already occurred. Malignant cells instantly absorb these nutrients, which can persuade them to convert to normal cells. Tumors given these nutrients tend to shrink and disappear. Regular chemotherapy destroys cancer cells and adds a toxic load onto the body as it attempts to clear cellular debris. Inositol and IP6 do not do this. Chemotherapy (intentionally) dampens the immune system. IP6 boosts the immune system, especially the Natural Killer (NK) cells that attack cancer. Cancer cells can become resistant to chemotherapy drugs. They cannot become resistant to the Inositol derivatives. IP6 increases the activity of the tumor suppressor gene, P53 by seventeen fold. The P53 gene is reponsible for inhibiting the pathway that allows normal cells to become cancerous.
IP6 has been used against a wide variety of cancers. Blood based cancers such as leukemia are the most sensitive, with solid tumors needing a larger dose. Most studies at this point have used either animals or human cancer cells in vitro (in a test tube). As an example, adding IP6 to human liver cancer cells resulted in complete inhibition of tumors. Human liver cancer cells injected into mice resulted in 71% tumors. Cells pretreated with IP6 resulted in no tumors. Pre-existing liver cancers regressed. In another study with Rhabdomyosarcoma, tumors were suppressed from 25 to 49 fold!
IP6 and Inositol have other properties, too. They are strong antioxidants. IP6 is also strongly anti-inflammatory. Asbestos given to rats resulted in lung inflammation and fibrosis. IP6 reduced this by from 6 to 30 fold!
IP6 reduces the incidence of kidney stones in those prone to them.
It is also useful in cardiovascular disease. IP6 inhibited platelet aggregation (stickiness) by 45% in rats. Platelet aggregation causes blood clots which cause heart attacks and stroke. Other studies with animals showed cholesterol lowered by 19% and triglycerides by 65% when IP6 was added to their chow.
IP6 inhibits hemoglobin S, the agent that is responsible for sickle cell anemia. This is the only known substance which affects the source of sickle cell anemia.
Inositol prevents fatty liver, prevents and treats the neural complications of diabetes, is an antidepressant (at high doses) and helps obsessive-compulsive disorder and panic attacks (also at high doses).CAUTIONS
IP6 is nontoxic. However, phytates are known to interfere with the absorption of zinc. For that reason, I suggest taking 15mg to 30mg of zinc with it. If you supplement for an extended time, blood mineral testing is also warranted (ideally, RBC minerals; serum zinc at a minimum).DOSE
The effects of IP6 are dose dependent. For daily prevention, from 1 or 2 capsules (500mg each) per day is sufficient. Those at high risk for cancer, fatty liver, kidney stones, etc. should take from 2 to 4 per day in two divided doses. Anyone with an active case of cancer should take from 5 to 8 capsules per day in two divided doses. Doses should be taken on an empty stomach.BRANDS